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Plant-based diets, ...
Plant-based diets, insulin sensitivity and inflammation in elderly men with chronic kidney disease.
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- González-Ortiz, Ailema (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat MEB, Nobels Väg 12A, Box 281, S-17177 Stockholm, Sweden; Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Nephrol & Mineral Metab Dept, Mexico City, DF, Mexico
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- Xu, Hong (author)
- Karolinska Institutet
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- Avesani, Carla M (author)
- Karolinska Institutet
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- Lindholm, Bengt (author)
- Karolinska Institutet
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden
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- Risérus, Ulf, 1967- (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden; Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med & Primary Care, Alfred Nobels Alle 23, S-14183 Huddinge, Sweden
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- Espinosa-Cuevas, Angeles (author)
- Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Nephrol & Mineral Metab Dept, Mexico City, DF, Mexico
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- Carrero, Juan Jesús (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-06-08
- 2020
- English.
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In: JN. Journal of Nephrology (Milano. 1992). - : Springer Science and Business Media LLC. - 1121-8428 .- 1724-6059. ; 33, s. 1091-1101
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Abstract
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- BACKGROUND: In persons with CKD, adherence to plant-based diets is associated with lower risk of CKD progression and death, but underlying mechanisms are poorly characterized. We here explore associations between adherence to plant-based diets and measures of insulin sensitivity and inflammation in men with CKD stages 3-5.METHODS: Cross-sectional study including 418 men free from diabetes, aged 70-71 years and with cystatin-C estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2 and not receiving kidney-specific dietetic advice. Information from 7-day food records was used to evaluate the adherence to a plant-based diet index (PBDi), which scores positively the intake of plant-foods and negatively animal-foods. Insulin sensitivity and glucose disposal rate were assessed with the gold-standard hyperinsulinemic euglycemic glucose clamp technique. Inflammation was evaluated by serum concentrations of C-reactive protein (CRP) and interleukin (IL)-6. Associations were explored through linear regression and restricted cubic splines.RESULTS: The majority of men had CKD stage 3a. Hypertension and cardiovascular disease were the most common comorbidities. The median PBDi was 38 (range 14-55). Across higher quintiles of PBDi (i.e. higher adherence), participants were less often smokers, consumed less alcohol, had lower BMI and higher eGFR (P for trend <0.05 for all). Across higher PBDi quintiles, patients exhibited higher insulin sensitivity and lower inflammation (P for trend <0.05). After adjustment for eGFR, lifestyle factors, BMI, comorbidities and energy intake, a higher PBDi score remained associated with higher glucose disposal rate and insulin sensitivity as well as with lower levels of IL-6 and CRP.CONCLUSION: In elderly men with non-dialysis CKD stages 3-5, adherence to a plant-based diet was associated with higher insulin sensitivity and lower inflammation, supporting a possible role of plant-based diets in the prevention of metabolic complications of CKD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Fruit
- Malnutrition
- Potasssium
- Protein-energy wasting
- Restriction
- Vegetable
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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González-Ortiz, ...
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Xu, Hong
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Avesani, Carla M
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Lindholm, Bengt
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Cederholm, Tommy
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Risérus, Ulf, 19 ...
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Ärnlöv, Johan, 1 ...
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Espinosa-Cuevas, ...
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Carrero, Juan Je ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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JN. Journal of N ...
- By the university
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Högskolan Dalarna
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Uppsala University
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Karolinska Institutet